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Insight to Inhibitor

"We are not measuring just one result – we are doing an overall assessment of how a new experimental treatment can potentially improve a person's overall health," says Udo Klein, Ph.D., head of the project team. "This is what makes this disease so difficult because it always manifests itself differently among people. But having these complex parameters provides a standardized index to measure the response across different patients and therapies. "

A New Molecular Frontier

Other ideas can come to deepen our understanding of immunological diseases at the molecular level." "Measure biomarkers that are indicative of the underlying causes of the disease and mechanism. Inhibition of BTK could be helpful in evaluating the effectiveness of treatment and potentially identifying the people most likely to benefit from a drug such as a BTK inhibitor. Identifying Predictive Biomarkers in rheumatoid arthritis and lupus for the inhibition of BTK is notoriously difficult because of the complexity of these conditions, but we are progressing.

"These types of diseases are not associated with diseased cells, such as cancerous tumors, "says Mike Townsend, associate director, Biomarker Discovery in Research." Rheumatoid arthritis and lupus are systemic diseases, requiring from the clinically accessible sites such as blood. "

This poses a number of distinct challenges. On the one hand, systemic biomarkers can be complex and it is not always easy to know where to determine a limit for defining a subpopulation, with a specific type of disease. Diseases like rheumatoid arthritis and lupus may also require examination of several cellular and molecular biomarkers to classify subtypes of diseases and diseases as there is not only one pathogenic factor

. Scheerens, Ph.D., Senior Director, OMNI-Biomarker Development in Development Sciences. "We find that there are certain biomarkers associated with particular types of inflammation, and this can lead to new ways of personalizing treatment or measuring the effectiveness of treatment earlier than ever before. "

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